The purpose of this study is to compare changes of minimally invasive arterial pulse contour cardiac output with changes of intermittent and continuous thermodilution cardiac output by pulmonary artery catheter in hemodynamic unstable patients with rapid changing vascular tone (changing dosage of vasoactive drugs or inotropics, or volume challenge). Simultaneously, global parameters of oxygen delivery and consumption will be compared with regional flow parameters and tissue oxymetry (near infrared spectrometry and laser-Doppler). While continuous thermodilution cardiac output is used for patient management, pulse contour cardiac output, intermittent thermodilution cardiac output and tissue oxymetry is only used for monitoring.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Attachment of the arterial line sensor and pulse contour cardiac output monitor to the arterial line of the patient.
Passive leg raising for prediction of fluid responsiveness with arterial pulse contour analysis.
Either a volume challenge (using colloids or crystalloids) or a change in the dosage of of vasoactive drugs or inotropics, or a combination of them, as proposed by the treating physician.
Tissue oxymetry continuously measured with near infrared spectrometry and laser Doppler during the whole study period.
Department of Intensive Care Medicine, University Hospital Inselspital, Berne
Bern, Switzerland
Changes of cardiac output measured by three different techniques during changes of vascular tone
Time frame: 2 hours
Prediction of fluid responsiveness with minimally invasive arterial pulse contour analysis in hemodynamic unstable patients.
Time frame: 2 hours
Comparison of global parameters of oxygen delivery and consumption with local parameters of flow and tissue oxymetry during changes of vascular tone.
Time frame: 2 hours
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