Feasibility and Reproducibility of Barostat Assessments of Colorectal Sensation During Colorectal Distention and Its Pharmacological Modulation Using Octreotide

Inclusion Criteria: * A positive diagnosis of IBS. * Subjects must either have been surgically sterilized, hysterectomized at least 6 months prior to screening, be postmenopausal or be using a double-barrier local * contraception. * Able to communicate well with the investigator, to understand and comply with the requirements of the study. Understand and sign the written informed consent Exclusion Criteria: * History of or evidence for structural diseases/conditions that affect the gastrointestinal system. * Other diseases or conditions that in the opinion of the Investigator significantly affect colorectal sensitivity. * Evidence of occult blood at stool analysis, or history of rectal bleeding. * Using or planning to use drugs or agents during the study period that alter GI physiology and visceral perception.