Nasopharyngeal 24 Hour pH Monitoring in Health Adult Volunteers

University of California, Davis

Overview

Involves a 24-hour pH probe study using the Dx-pH Measurement System on patients who do not have symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease to establish normal values for the Dx-pH Measurement System.

The specific aim of this study is to establish the normal range of values in an adult population with no symptoms of laryngopharyngeal reflux disease or gastroesophageal reflux disease using the Dx-pH Measurement System.

Study Type

INTERVENTIONAL

Allocation

Masking

NONE

Conditions

Gastroesophageal Reflux Disease

Interventions

Dx-pH Measurement ProbeDEVICE

Dx-pH Measurement Probe measures gaseous pH values in the nasopharynx and oropharynx over a period of 24 hours.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * no symptoms of laryngopharyngeal reflux or gastroesophageal reflux disease * score less than 10 on Reflux Symptom Index Exclusion Criteria: * age less than 18 * known lidocaine allergy * history of heartburn, regurgitation, chronic cough, voice changes, globus pharyngeus, excessive throat clearing, or swallowing problems * score 10 or greater on Reflux Symptom Index * current or past antacid use or other antireflux therapy * history of antireflux surgery * pregnancy * current anticoagulation therapy (warfarin, heparin, aspirin, clopidogrel bisulfate) * special/vulnerable populations (children, mentally handicapped, pregnant women, fetuses, prisoners, cognitive impairment, life-threatening disease, social or economic disadvantage)

Locations (1)

University of California Davis Medical Center

Sacramento, California, United States

Outcomes

Primary Outcomes

To develop a range of normal values in adults without symptoms of laryngopharyngeal reflux.

Time frame: At completion of study

Data from ClinicalTrials.gov

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