Evaluation of Kidney Disease in Liver Transplant Recipients

University of Wisconsin, Madison

Overview

A non-invasive urinary test that detects kidney injuries in liver transplant (LT) candidates would be useful for monitoring of kidney damage. Particularly, the ability to predict irreversibility of such renal damage or progressive nature of renal disease in LT candidates would be of importance to determine the need for dual kidney-liver transplantation (KLT) versus LT alone. We will correlate kidney histology with cytokine/chemokine profile expression in the urine as a potentially useful noninvasive diagnostic tool.

Study Type

OBSERVATIONAL

Conditions

Kidney Disease Liver Transplantation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects on the liver transplant wait list, subjects who have received a liver transplant at least 6 months prior to enrollment, or subjects who have normal liver function and are about to undergo kidney biospy for diagnostic purposes. Exclusion Criteria: * Contraindication to kidney biopsy * Inability to give informed consent

Locations (1)

University of Wisconsin

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

To determine the value of urinary levels of chemokines in the distinction between types of kidney disease in the setting of liver failure

Time frame: 1 year

Data from ClinicalTrials.gov

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