Effect of Chronic Statin and Viagra Therapy in Persons With Endothelial Cell Dysfunction

Mayo Clinic

Overview

To determine if 6 weeks of daily treatment with Atorvastatin 40 mg alters the immediate effect of Sildenafil Citrate (Viagra, Pfizer Inc, New York, NY) on endothelial function (activity of the artery) as measured by noninvasive peripheral arterial tonography in men and women. Also, to determine if 6 weeks of daily treatment with Atorvastatin 40 mg affects erectile function in men

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Conditions

Endothelial Dysfunction

Interventions

AtorvastatinDRUG

40 mg atorvastatin pill daily

placeboDRUG

40 mg pill per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing coronary angiography * No previous statin use * Age \> 18 years old * No PDE5-1 use in the past 6 months Exclusion Criteria: * Patients with an Acute Coronary Syndrome * Patients with Cardiogenic shock * Patients \> 30% coronary stenosis * Patients with unexplained muscle pain * Patients with acute liver disease * Patients receiving immunosuppressant therapy, azoles, macrolide antibiotics, niacin, L-arginine * Patients with serum creatinine \> 2.0 * Patients with total cholesterol \> 200 mmol/l * Patients on current statin therapy or clinically indicated to be on statin therapy

Outcomes

Primary Outcomes

To determine if endothelial function as measured by Peripheral Arterial Tonometry improves over a 6 week period while on Atorvastatin.

Time frame: 6 weeks

Secondary Outcomes

To determine if treatment with Atovastatin affects erectile function in men

Time frame: 6 weeks

Data from ClinicalTrials.gov

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