Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

Mayo Clinic18 enrolled

Overview

The purpose of this study is to determine if a new MR pulse sequence is accurate in determining how much iron is in the liver.

Quantification of liver iron requires liver biopsy and histological assessment. New rapid MR techniques allow determination of liver relaxation times that can be altered with increasing iron deposition. The purpose of this study is to compare the results obtained with MRI to liver biopsy and iron quantification in patients undergoing liver biopsy in the setting of hemochromatosis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hemochromatosis

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Undergoing liver biopsy for suspected or known hemochromatosis * Undergoing liver biopsy for living-related liver donation evaluation Exclusion Criteria: * Contraindication to MRI

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Accuracy of MR in quantifying liver iron

Time frame: one time point

Data from ClinicalTrials.gov

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