The purpose of this study is to develop new ways of imaging fatty blockages in the leg arteries to improve upon techniques used now and to develop new ways of understanding how new treatments may affect the disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
85
University of Virgina Health System
Charlottesville, Virginia, United States
Plaque Volume
SFA plaque volume
Time frame: 2 years
Perfusion Index
Perfusion index is a MRI measure of calf muscle perfusion indexed to the arterial input. The value is between 0 and 1 with 0 being worst and 1 being best.
Time frame: 2 years
Phosphocreatine Recovery Time Constant - the Time it Takes for Phosphocreatine Levels to Recover to Plateau.
Phosphocreatine recovery time constant is the time it takes for phosphocreatine levels to recover to plateau after the completion of exercise. This ranges from 20 to 1000 seconds. 20-40 seconds is normal and any value over 40 seconds is abnormal.
Time frame: 2 years
Low Density Lipoprotein Cholesterol
Time frame: 2 years
Total Cholesterol
Time frame: 2 years
High Density Lipoprotein Cholesterol
Time frame: 2 years
Triglycerides
Time frame: 2 years
Magnetic Resonance Angiographic Index
MRA index is a measure of angiographic severity of disease. 0 = no disease and 4 is severe disease.
Time frame: 2 years
Log Treadmill Exercise Time
Time frame: 2 years
6-minute Walk Distance
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Time frame: 2 years
V02 - Maximal Oxygen Consumption
Time frame: 2 years