Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities

Yale University5 enrolled

Overview

The purpose of this study is to determine whether dynamic contrast enhanced MRI (DCE MRI) and high diffusion weighting MRI may be used to distinguish between favorable and unfavorable responses to therapy of glioblastoma multiforme. Imaging data will be correlated with histopathologic findings and clinical responses to radiation therapy with or without chemotherapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glioblastoma Multiforme

Interventions

dynamic contrast enhanced magnetic resonance imagingOTHER

dynamic contrast enhanced MRI using contrast agent gadodiamide

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The presence of a primary brain tumor that cannot be completely resected that requires radiation therapy with or without chemotherapy. Exclusion Criteria: * Patients who do not have a primary brain tumor or who are unable to tolerate the environment of the MRI scanner

Locations (1)

Yale University School of Medicine

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

To detect the early "local" treatment responses from the physician recognized GBM "gross tumor volume" (GTV)

Time frame: Upon completion of study

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.