C-reactive Protein and Endothelial Dysfunction in Women With Glucose Intolerance

Yale University46 enrolled

Overview

The goal of this study is to determine whether markers of vascular inflammation (such as c-reactive protein) can predict endothelial dysfunction (as measured by flow-mediated dilation) in postmenopausal women with glucose intolerance compared to normal controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glucose Intolerance

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy postmenopausal women * ages 40-65 Exclusion Criteria: * smokers * diabetes requiring medication

Locations (1)

Yale Center for Clinical Investigation

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

c-reactive protein

Time frame: performed after screening evaluation

Secondary Outcomes

flow-mediated dilation of brachial artery

Time frame: performed twice after screening visit

sex steroids

Time frame: performed after screening visit

Data from ClinicalTrials.gov

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