To test the hypothesis that localized functional reentry maintains Afib in humans, ibutilide will be administered intravenously in patients undergoing an Afib ablation. The hypothesis of this study is that ibutilide will decrease the high frequency signals observed in Afib suggesting the presence of micro reentrant circuits as the basic mechanism of Afib, especially for the paroxysmal Afib group. The potential difference in response to the ibutilide in patients with paroxysmal versus persistent Afib may show the difference in the underlying mechanism of Afib between these two groups.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
50
During scheduled radio frequency ablation for atrial fibrillation patients will be infused with 1mg of ibutilide over 10 minutes.
Medical Consultants, P.C.
Muncie, Indiana, United States
RECRUITINGTo discern the basic mechanism of Afib by studying its response to Ibutilide administration.
Time frame: one year
To compare the ibutilide response in patients with paroxysmal versus permanent Afib
Time frame: one year
To study the subgroup of patients that converted to sinus rhythm in order to identify various factors that may have increased their susceptibility to ibutilide.
Time frame: one year
To improve the current results of pulmonary vein isolation by performing a procedure guided by ablation of high dominant frequency areas.
Time frame: One year
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