Clinical and Molecular-Metabolic Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas

Inclusion Criteria: * Patients must have shown unequivocal evidence for tumor progression by MRI or CT scan. * Patients must be on a stable or decreasing dose of corticosteroids for a minimum of 5 days before the baseline MRI and PET scans. * Patients must have failed prior radiation therapy. * Patients with prior therapy that included interstitial brachytherapy or stereotactic radiosurgery (including gamma-knife or cyber-knife) must have confirmation of true progressive disease rather than radiation necrosis based upon either PET or Thallium scanning, and/or MR spectroscopy, and/or MR Perfusion, and/or surgical documentation of disease. * All patients must sign an informed consent indicating that they are aware of the investigational nature of this study. Patients must have signed an authorization for the release of their protected health information. * Age \> 18 years old, and with a life expectancy \> 8 weeks. * Karnofsky Performance Status ≥ 50% * Patients must have recovered from all acute toxicities from prior therapies. At least 28 days must have elapsed since prior radiation. * Patients must have adequate bone marrow function * Patients must agree to practice adequate contraception. Exclusion Criteria: * Patients must not be taking EIAEDs * Patients must not have any significant medical illnesses or other history that in the investigator's opinion cannot be adequately controlled with appropriate therapy or would compromise the patient's ability to tolerate this therapy. * Patients with a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix), unless in complete remission and off of all therapy for that disease for a minimum of 3 years are ineligible. * Patients must not have active infection or serious intercurrent medical illness. * HIV-Positive patients receiving combination anti-retroviral therapy are excluded from the study due to possible retro-viral drug interactions. * Patients must not have any disease that will obscure toxicity or dangerously alter drug metabolism.