The Influence of Probiotics on Vancomycin-Resistant Enterococcus

Oregon Health and Science University8 enrolled

Overview

Drinking probiotics in a the form of a yogurt drink will restore normal gastrointestinal (GI) bacteria in patients whose colon are colonized with vancomycin-resistant enterococcus (VRE).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

GI Colonization of Vancomycin-resistant Enterococcus

Interventions

probioticsDIETARY_SUPPLEMENT

100 gms of a yogurt drink containing probiotics will be given to pVRE positive patients for 4 weeks

yogurtDIETARY_SUPPLEMENT

100 gms of pasteurized yogurt drinks with no live cultures will be given to VRE positive patients for 4 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * VRE positive patients with GI colonization Exclusion Criteria: * Age less than 18 years * Patients who have had a bone marrow transplant * Extreme short bowel patients (less than 100 cm small bowel remaining) * Patients with active VRE infection but no GI colonization * Patients unable to eat and have no feeding access * Patients who do not have a power of attorney to give consent if they are unable to

Locations (1)

OHSU hospital

Portland, Oregon, United States

Outcomes

Primary Outcomes

Whether a positive VRE colonized patient becomes VRE negative after drinking yogurt with probiotics

Time frame: 4 weeks

Secondary Outcomes

Time to VRE clearance

Time frame: 4 weeks

Sustainable effects of probiotics on VRE colonization

Time frame: 8 weeks

Any positive or negative effects on patients' hospital stay.

Time frame: 8 weeks

Data from ClinicalTrials.gov

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