Primary research questions/Purpose of the Research. 1. Determine the short term (epidermal regeneration, reduction of pain, infections and length of stay) and long term (scarring, long term recovery, and cost of treatment) outcomes of Microbial Nanocellulose (NC) and fine mesh gauze impregnated with hyaluronan and thrombin (HT). 2. Determine if donor site treatment with NC and HT is as safe as the use of Scarlet Red ointment dressing. b. Describe the importance of the knowledge that you expect to gain from the research. To find a donor site dressing that has outcomes equal or better than that of scarlet red.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Application of donor site dressing: scarlet red, Microbial Nanocellulose (NC), or hyaluronan and thrombin (HT).
Obtain blood specimen at surgery donor site harvest, 14 days post surgery and 6 months post surgery
Tissue biopsy of donor site treated area at admission, wound healing and 2-6 months post burn.
epidermal regeneration (donor site healing)
Time frame: Days 3-14 post surgery
Infection
Time frame: Days 0-21 post surgery
reduction in pain of donor site
Time frame: Day 0-21 post surgery
Scarring
Time frame: Day 7 post surgery to 2 years post surgery
Costs
Time frame: Admission post burn injury to 2 years post burn injury
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