The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better.
* Participants will be assigned to a dose level by random chance, like flipping a coin. * A treatment plan will be determined by a treatment planning CT scan and will either involve 40-44 treatments or 37-40 treatments.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
381
Radiation doses will be determined by planning CT
Massachusetts General Hospital
Boston, Massachusetts, United States
Acute Toxicity
Time frame: 90 days
Establish local control rates for both dose schedules.
Time frame: 5 years
To provide date to be used as the basis for choosing the dose of charged particle radiation for chordomas of the base of skull and the cervical spine.
Time frame: 5 years
Late Toxicity
Time frame: 5 Years
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