LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin

Inclusion Criteria: 1. Signed informed consent 2. Males or females aged 18 to 75 years. Female patients must be non-fertile. To be considered as non-fertile, females must fulfil the following: * Non-nursing and non-pregnant 12 months prior to enrolment * Not of child bearing potential ie, either documented irreversible surgically sterile (bilateral oophorectomy or hysterectomy is acceptable, but not tubal ligation) or post-menopausal. Post-menopausal is defined as serum follicle-stimulating hormone (FSH) levels in the post-menopausal range combined with amenorrhea for more than 1 year in a woman above 50 years of age, or amenorrhea for more than 2 years below 50 years of age 3. Patients with hypercholesterolemia treated with stable doses of the below listed lipid lowering medication for at least 3 months prior to randomization * Atorvastatin not more than 20 mg/day or * Simvastatin not more than 40 mg/day 4. LDL-cholesterol \> 3.0 mmol/L (Week -1) 5. Subject able and willing to comply with all study requirements 6. At randomization, diet as instructed by the investigator during the last 4 weeks prior to randomization and willingness to follow these instructions throughout the study Exclusion Criteria: 1. Cholesterol lowering agents other than the defined statins 2. History of somatic or psychiatric disease/condition, which may interfere with the objectives of the study as judged by the investigator 3. Clinically significant illness or clinically relevant trauma within 2 weeks before the administration of the investigational product as judged by the investigator 4. Chronic (\> 3 months) pain condition requiring daily medication with pain killers 5. Glycosylated haemoglobin (HbA1c) \> 7.0% 6. Diabetes requiring medication other than metformin 7. Clinically abnormal physical findings and laboratory values as judged by the investigator and abnormal resting ECG, eg, QTc interval \> 450 msec 8. Body Mass Index of ≥ 40 kg/m2 9. Resent history (\< 3 month) of stroke or transient ischemic attacks 10. History of seizure disorder, except febrile convulsions 11. A current diagnosis of cancer, unless in remission 12. Blood pressure (BP) of \> 160/95 mm Hg 13. History of cardiac arrhythmia, such as intermittent supraventricular tachyarrhythmia and atrial fibrillation 14. Unstable angina pectoris, myocardial infarction or coronary bypass graft surgery or percutaneous coronary intervention \< 6 month before randomization 15. Congestive heart failure New York Heart Association Class \> 2 16. Unstable or severe angina pectoris or peripheral artery disease 17. Known thyroid disease or thyroid biomarkers (TSH, T3, free T3, T4, free T4) outside reference range for normal at enrolment and at baseline 18. Positive urine pregnancy test in women at enrolment 19. Use of thyroid replacement therapy and hormone replacement therapy (including contraceptive pills) for last 3 months before randomization