International Registry and Biorepository for TMA(Thrombotic Microangiopathy)

Northwell Health6 enrolled

Overview

This registry will collect clinical data and store biosamples (seru, plasma, urine, and DNA) annually from pediatric patients with thrombotic mcroangiopathy

Children age, 6 months - 18 years, are eligible if they have one of the following categories of thrombotic microangiopathy (TMA):(1) severe D+HUS; (2) non-familial atypical HUS; (3) familial atypical HUS; or (4) TTP Patients are seen intially and annually thereafter Biosamples are collected for storage annually.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thrombotic Microangiopathy Hemolytic Uremic Syndrome Thrombotic Thrombocytopenic Purpura

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Severe HUS, familial or non-familial atypical HUS, TTP Exclusion Criteria: * None

Locations (1)

Schneider Chldren's Hospital

New Hyde Park, New York, United States

Outcomes

Primary Outcomes

Determine epidemiology and outcomes of the various forms of TMA

Time frame: Ongoing

Determine genetic causes of TMA

Time frame: Ongoing

Secondary Outcomes

Initiate clinical trials in TMA

Time frame: In the future

Data from ClinicalTrials.gov

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