This study will compare the effect of two intravenous solutions on eye pressure during spine surgery in the following groups: Group A - Lactated Ringer's replacement for blood loss and placebo eye drops Group B - Lactated Ringer's replacement for blood loss and brimonidine eye drops Group C - Albumin replacement for blood loss and placebo eye drops Group D - Albumin replacement for blood loss and brimonidine eye drops
Patients will be administered either brimonidine eye drops, or placebo eye drops, preoperatively, on the day of surgery and during surgery. Eye pressure will be measured before surgery, every 30 minutes throughout your surgery and every hour for 4 hours following surgery. Subjects will be evaluated before surgery and on days 5, 8, 15 after surgery. During these evaluations, the subject will be asked questions about recovery and his/her eyes will be checked by an ophthalmologist and vision will be tested.
Study Type
OBSERVATIONAL
Enrollment
60
Cleveland Clinic
Cleveland, Ohio, United States
The primary outcome will be the maximum intraocular pressure at any time during surgery.
Time frame: 15 days post surgery
Intraocular pressure as a function of surgical duration; Velocity of retrobulbar blood flow; Facial edema and or chemosis; Time to extubation; Duration of recovery Correlation between Dpp and FTc.
Time frame: 15 days post surgery
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