Preimplantation Genetic Screening in Women Over 35 Year

KU Leuven100 enrolled

Overview

In view of insufficient evidence to routinely use Preimplantation Genetic Screening (PGS) to improve success rates after IVF, we test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer (ET) of chromosomally normal embryos following PGS compared to patients who had an ET without PGS. In a randomized controlled trial (RCT) in patients with AMA (≥ 35 years), the clinical IR per embryo transferred will be compared after ET on day 5 or 6 between the PGS group (embryo biopsy and analysis of chromosomes 13, 16, 18, 21, 22, X and Y) and the control group without PGS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

In Vitro Fertilization

Interventions

Preimplantation genetic screening after embryo biopsyPROCEDURE

Preimplantation genetic screening after embryo biopsy

Eligibility

Sex: ALLMin age: 35 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All couples with a medical indication for IVF and with a female age of at least 35 years are invited to participate in the study. Exclusion Criteria: * Cycles were excluded from the study if ≤ 2 fertilized oocytes were available on day 1 after oocyte retrieval (OR), or if ≤ 2 ≥ 6c stage embryos were available on day 3 after OR.

Locations (1)

Leuven University Fertility Center

Leuven, Belgium

Outcomes

Primary Outcomes

Clinical implantation rate per embryo transferred

Time frame: end of study

Secondary Outcomes

Pregnancy rate per transfer

Time frame: end of study

Data from ClinicalTrials.gov

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