Efficacy Study of Methylphenidate Hydrochloride to Reduce Fatigue in Prostate Cancer Patients Receiving Hormone Therapy

Inclusion: * Age \> 18 and ≤ 85 years * Histologically confirmed prostate cancer * Currently receiving LHRH-agonist therapy for greater than 6 months with measurable fatigue, defined as a score of \>1 on the Bruera global fatigue severity scale OR * Deemed eligible to commence LHRH-agonist therapy, with confirmation of fatigue at Screening Visit 2 * Have a serum PSA which is stable or decreasing based on the PSA trend over the last 2 values taken at least 2 months apart, with the more recent value taken at least 2 months after initiation of LHRH-agonist therapy. * Have adequate liver and renal function (Bilirubin ≤ 1.5 x ULN and AST, ALT and Serum Creatinine \< 2 x ULN) * Able to swallow and retain oral medication * Life expectancy of at least 1 year * Able to read and write in English (and therefore accurately complete the required study questionnaires), understand instructions related to study procedures and give written informed consent. Exclusion: * Current malignancy or received treatment for a previous malignancy within the last 3 years other than prostate cancer (other exceptions are superficial bladder cancer or non-melanoma skin cancer) * Previous chemotherapy within the last 5 years * Anemia (Hemoglobin \< 100 g/L) * Myocardial infarction within past 6 months * Any unstable serious co-existing medical condition(s) including but not limited to ; unstable or poorly controlled coronary artery disease, chronic atrial fibrillation, uncontrolled hypertension, uncontrolled diabetes, Severe bleeding diseases or immune disorders * Severe depression as defined by CES-D score \>27 * History of motor tics, seizures or a family history of Tourette's syndrome * Infection with HIV (Human Immunodeficiency Virus), HBV (Hepatitis B) or HCV (Hepatitis C) * Evidence of drug or alcohol abuse * Known hypersensitivity to methylphenidate * Possess any other contraindications to methylphenidate use