A Study Evaluating the Effects of CLAG With Gleevec in Refractory or Relapsed Acute Myeloid Leukemia

Inclusion Criteria * Men and Women of all ethnic groups whose age is ≥ 18 years old. * Diagnosis of AML or CML blast crisis, according to WHO criteria, except acute promyelocytic leukemia AML-M3 FAB subgroup. * Refractory or Relapsed AML. * Refractory AML is defined as failure to achieve CR after 2 cycles of induction chemotherapy or persistent (\>40%) bone marrow blasts after one cycle of chemotherapy induction. * Relapsed AML is defined as any evidence of disease recurrence after achieving CR. Early relapse is defined as that occurring within 12 months and late relapse is defines as that occurring after 12 months. * ECOG performance status of 0 or 1. * Patients must sign a written informed consent. * Females of childbearing potential must not be pregnant or actively nursing a child. They must have a negative pregnancy test 7 days before initiation of study drug administration. * Postmenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. * Male and females of reproductive potential must agree to employ an effective barrier method of birth control throughout the duration of the trial and for 3 months following study medication discontinuation. Exclusion Criteria * Abnormal Kidney Functions: creatinine ≥2.5mg/dL; if creatinine is between 2.0-2.5, patient should have GFR measured and the dose of Cytarabine may be adjusted accordingly. * Abnormal Liver Functions: Bilirubin .2mg/dL, transaminases (AST/ALT) more that 2.5 times the institutional upper limits of normal (IULN) * Systemic active infection, unless controlled on active therapy. * Patients with Grade III/IV cardiac problems as defined by the New York Heart Association Criteria ( i.e., congestive heart failure, myocardial infarction within 6 months of the study), EF 30%. * Patient has known chronic liver disease (i.e., chronic active hepatitis and cirrhosis). * Patient has known diagnosis of human immunodeficiency virus (HIV) infection. * History of other curatively untreated malignancy, except non-melanotic skin cancers. * Patients that have received investigational agents within 1 month of study entry. * History of allergic reaction attributed to compounds of similar chemical or biologic composition to Gleevec or any component of the CLAG regimen.