Improving Therapeutic Outcomes in the Tongue Carcinoma Patient: Assessment of Adaptation Using Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging

Inclusion Criteria: Inclusion criteria for the tongue carcinoma patients: * Primary malignancy of the oral or base of tongue, Stage I-IV of AJCC staging system, planned for surgical or radiation therapy. Inclusion criteria for the healthy subjects: * Healthy adult subjects between the ages of 21-75 years. Exclusion Criteria: Exclusion criteria for the tongue carcinoma patients include the following: * History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia), * History of the following neurological conditions: CVA, seizure disorders, demyelinating conditions, systemic neuromuscular disorders, cerebral palsy, Alzheimer's disease. * History of previous moderate to severe traumatic brain injury. * History of significant cardiovascular, respiratory, gastrointestinal or renal disease (e.g.myocardial infarction within the previous 12 months, significant vaso-occlusive disease,severe or advanced asthma, COPD, emphysema, gastroesophageal reflux disease, or renal compromise) * History of achalasia * History of other neoplasms involving the brain, head and neck, or gastrointestinal system. * History of dysphagia, odynophagia, or aphasia unrelated to present illness. * History of significant claustrophobic reactions. * Standard contraindications to MR examinations (e.g. implanted stimulators). Exclusion criteria for the healthy subjects includes the all of the conditions listed for the tongue: * Carcinoma patients and additionally includes history of significant surgery or previous radiation therapy to the head and neck * Previous history of dysphagia, odynophagia, aphasia, pregnancy,and standard contraindications to MR examinations.