Peripheral Venous Oxygen Saturation and Biomarkers to Estimate Cardiac Output and Filling Pressures in Heart Failure

Massachusetts General Hospital30 enrolled

Overview

The relationship between peripheral venous saturation and central hemodynamics (including right and left heart filling pressures and cardiac output), mixed venous oxygen saturation, and contemporary biomarkers of heart failure is not clear. We aim to determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure. We will determine the relationship between cardiac output measured via thermodilution and the Fick equation calculated using concurrent oxygen saturations from the distal PA, central vein, and peripheral vein. We also aim to examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Congestive Heart Failure

Interventions

Standard of care therapy for severe decompensated heart failureOTHER

Standard of care therapy for severe decompensated heart failure

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

The following inclusion criteria will be utilized: 1. Age\>21 2. PA-catheter insertion for therapy of congestive heart failure decided upon by the attending cardiologist The following will be considered as exclusion criteria for this study 1. Known or suspected septic shock or bacteremia 2. Active bleeding or HCT\<24% at baseline 3. Arterial oxygen saturation \<90% at baseline despite supplemental oxygen therapy. 4. Previous difficulty with venipuncture of upper extremity veins or the presence of a surgical arteriovenous fistula for hemodialysis 5. Insertion of the PA catheter through the femoral vein 6. Subjects unwilling or unable to provide written consent

Outcomes

Primary Outcomes

To determine the relationship between mixed venous, central venous, and peripheral venous oxygen saturation in patients with advanced (class III or IV) heart failure.

Time frame: Day 0-5 of 'tailored' heart failure therapy

Secondary Outcomes

To examine the relationship of selected cardiac biomarkers with cardiac filling pressures and cardiac output over time in patients with decompensated heart failure.

Time frame: Days 0-5 of 'tailored' heart failure therapy