Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression

Charite University, Berlin, Germany30 enrolled

Overview

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Chronic Depression

Interventions

DuloxetineDRUG

Duloxetine 30mg up to 120mg per day.

Cognitive Behavioural Analysis System of PsychotherapyBEHAVIORAL

Cognitive Behavioural Analysis System of Psychotherapy (CBASP): 20 sessions of psychotherapy, beginning with twice weekly, then weekly sessions.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission) * HAMD-24\>20 Exclusion Criteria: * Concurrent Psychotherapy or Psychopharmacotherapy * Previous Non-Response to Duloxetine * Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode * Serious Psychiatric comorbidity * Serious Neurologic comorbidity * Contraindications to Duloxetine * Contraindications to fMRI

Locations (1)

Charité Universitätsmedizin

Berlin, State of Berlin, Germany

Outcomes

Primary Outcomes

Neuroimaging Data (fMRI)

Time frame: Before and After Therapy

Secondary Outcomes

HAMD

Time frame: Weekly

Salivary Cortisol

Time frame: Before and After Therapy

Data from ClinicalTrials.gov

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