Genetic Susceptibility to Lung Cancer in Never Smokers

Inclusion Criteria: * Cases will be eligible for inclusion if: * They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and * They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected) * They speak and read English * They understand and agree to sign informed consent, and * They agree to give us a blood sample, and * They agree to complete the study questionnaire, and * They agree to have their pathology information reviewed by study personnel. * Controls will be eligible for inclusion if: * They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and * They speak and read English * They understand and agree to sign informed consent, and * They agree to give us a blood sample, and * They agree to complete the study questionnaire. Exclusion Criteria: * Subjects who do not meet the inclusion criteria for either the case or control groups will not be eligible for this study. * All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).