Antibody and Safety Study of 6 Doses of NicVAX in Smokers

Inclusion Criteria: * Healthy smoker, ≥10 cigarettes per day for 6 months, exhaled carbon monoxide ≥10 ppm * Written informed consent * Negative urine pregnancy test, and willing to use birth control during the study, if applicable Exclusion Criteria: * Prior exposure to nicotine vaccine * Clinically significant allergic reactions, especially to components of the vaccine * Serious or unstable clinical disease within the past 6 months * Use of any smoking cessation therapy within 30 days preceding 1st dose * Immunosuppression, due to: steroids or other immunosuppressants in the last 30 days, history of cancer or cancer treatment in the last 60 months, known HIV infection, or congenital or acquired immunodeficiency * Use of any vaccine other than influenza vaccine within 30 days prior to each study dose * Use of another IND drug or device within 30 days preceding 1st dose * Inability to follow the protocol, or illicit drug use in the past 12 months, or psychiatric disorder in the past 3 months