Azithromycin in the Treatment of M. Avium Complex Lung Disease

Inclusion Criteria: * Meet American Thoracic Society criteria for nontuberculous lung disease: two or more AFB smear positive, culture positive sputums or bronchoscopic samples and/or two or more AFB smear negative respiratory samples with moderate to heavy growth (2+-4+); abnormal CXR consistent with M. avium lung disease; abnormal CXR consistent with M. avium lung disease; absence of other lung pathogens (except for the coexistence of M. abscessus). * Age 18 and older * Pretreatment isolate of M. avium complex available for MIC determination Exclusion Criteria: * History of macrolide allergy * Received macrolide therapy in last two months * Children less than 18 years of age * If a menstruating female, not pregnant and on adequate birth control