Evaluation of Probiotics on Symptoms of Upper Respiratory Tract Infections

Danisco326 enrolled

Overview

The aim of the present prospective study is to investigate whether the consumption of certain probiotic strains over a six-month winter/spring season would be able to affect the incidence and duration of upper respiratory tract infections, in otherwise healthy children as well as determining whether a combination of two strains would perform differently from a single strain version.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

326

Conditions

Healthy

Interventions

PlaceboDIETARY_SUPPLEMENT

Inert excipient

Lactobacillus acidophilus NCFMDIETARY_SUPPLEMENT

1e10 CFU/day

Combination of Lactobacillus acidophilus and Bifidobacterium lactisDIETARY_SUPPLEMENT

1x10e10 CFU/day

Eligibility

Sex: ALLMin age: 3 YearsMax age: 5 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 3-5 years of normal nutritional status and health Exclusion Criteria: * Contraindications to dairy products (lactose intolerance or cow's milk allergy) * Indicators of inflammatory disease, intestinal disease, Crohn's disease, colitis, celiac disease * Chronic cough from recurring respiratory distress-related diseases * Hirschsprung's disease * Cystic fibrosis * Other metabolic, neurological, or anatomic alteration that predisposes participation * Intake of probiotics within the last 3 weeks

Locations (1)

Day care center

Jinhua, Zhejiang, China

Outcomes

Primary Outcomes

To examine if the consumption of two different probiotic strains added to milk at the point of consumption could reduce the "flu-like" symptoms and other symptoms of illness of preschool-age children in day care centers.

Time frame: Daily for six months

Secondary Outcomes

To determine if children who consume a beverage fortified with a probiotic miss fewer days of preschool as measured by illness.

Time frame: Six months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.