Allogeneic Stem Cell Transplantation (SCT) After Dose-reduced Conditioning for Myelofibrosis Patients

Inclusion Criteria: * Disease: Histologically proven Myelofibrosis with myeloid metaplasia/MMM defined as per the Italian Consensus Conference on MMM diagnosis with either primary MMM or secondary to Polycythaemia vera or essential thrombocythaemia with * "intermediate risk" or "high risk" score according to the Lille Scoring System * OR "low risk" score according to the Lille Scoring System with constitutional symptoms (fever, night sweat, weight loss \> 5% of body weight) * OR "high risk" score according to the Cervantes score * Age: * Patients between 50 and 70 years of age and no limited life expectancy for other reasons than MMM * Patients under 50 years of age who are not eligible for a standard myeloablative conditioning, (e.g., because of prior autologous stem cell, history of severe infections like fungal infections, history of cardiac toxicity or other reasons according to the treating physician) * HLA compatible or identical donor, related or unrelated (one mismatch allowed) * Written informed consent of the patient Exclusion Criteria: * Positive search for bcr-abl on blood. * Serious irreversible renal, hepatic, pulmonary or cardiac disease * Central nervous involvement * Positive serology for HIV * Pregnant or lactating women * Patients with a life-expectancy of less than six months because of another debilitating disease * Serious psychiatric or psychological disorders