Language Function in Patients With Brain Tumors

Memorial Sloan Kettering Cancer Center7 enrolled

Overview

The purpose of this study is to use an imaging method called functional magnetic resonance imaging (fMRI) in patients who have a tumor near an area of the brain that is believed to control language. The fMRI is a new kind of imaging that uses a strong magnetic field to look at functioning brain tissue. This kind of imaging will be used to study the effect of the brain tumor on your speech.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain Cancer CNS Cancer

Interventions

fMRI Scan, pre- and post language evaluationOTHER

All subjects will undergo functional MR imaging, pre- and post-surgical language evaluation, and electrocortical stimulation mapping. The brain tumor patients will undergo these procedures twice.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient in whom a tumor invades or is directly adjacent to the expected location of one of the language centers. * At least 18 years of age * English as first language Exclusion Criteria: * Patients with high grade tumors * History of significant psychiatric condition (e.g. schizophrenia, obsessive-compulsive disorder, significant dementia), * History of the following neurological conditions: CVA, demyelinating conditions, cerebral palsy, Alzheimer's disease. * History of significant claustrophobic reactions. * Pregnancy * Standard contraindications to MR examinations (e.g. implanted stimulator) * Patients, who were treated prior to our first scan, will not be eligible to participate in this study

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Outcomes

Primary Outcomes

To identify language organization prior to surgery in patients in whom a tumor invades or is directly adjacent to the expected location of one of the language centers.

Time frame: conclusion of study

Secondary Outcomes

To assess language reorganization over time.

Time frame: conclusion of study

Data from ClinicalTrials.gov

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