RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. PURPOSE: This clinical trial is studying the side effects of partial breast radiation therapy and how well it works in treating women undergoing breast conservation therapy for early-stage breast cancer.
OBJECTIVES: * To allow women undergoing breast conservation therapy for early-stage breast cancer to have access to accelerated partial breast irradiation therapy on a controlled trial. * To capture prospective data on acute and late toxicity and disease recurrence in patients treated with this therapy. * To summarize the institutional experience of these patients treated with this experimental therapy. OUTLINE: Within 9 weeks after surgery, patients undergo accelerated partial breast irradiation (including conformal external-beam irradiation, interstitial brachytherapy, intracavitary brachytherapy, or proton beam irradiation) twice daily for 5 days (10 fractions). After completion of study therapy, patients are followed every 3 to 6 months for at least 5 years and then annually thereafter.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
28
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Acute toxicity as assessed by NCI CTC at 1 week, 4 weeks, and 3 months after completion of study therapy
Time frame: 11 months
Late toxicity and cosmesis as assessed at or before 3 years from the start of radiotherapy and every 3 months during follow-up
Time frame: 11 months
Site of disease recurrence (i.e., local, regional, or distant)
Time frame: 11 months
Time to recurrence
Time frame: 11 months
Time to locoregional recurrence
Time frame: 11 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.