Measurements of Resting Energy Expenditure in Patients With or at Risk of Developing Graft Versus Host Disease

Ann & Robert H Lurie Children's Hospital of Chicago20 enrolled

Overview

This study aims to show that the MedGem indirect calorimetry measurement device will be feasible to use in children with GVHD. Also, it aims to show that children with chronic GVHD will have elevated REE that is not adequately predicted by standard equations.

Chronic Graft versus Host Disease (GVHD) is an important cause of morbidity and mortality in patients undergoing allogeneic bone marrow and hematopoietic progenitor cell transplantation. In adults, it has been shown that patients with acute or chronic GVHD have an increase in their resting energy expenditure (REE), likely as a result of chronic systemic inflammation. These studies have not yet been performed in children. This study's objective is to determine the REE of pediatric patients with acute and chronic GVHD after hematopoietic stem cell transplantation (HSCT).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Graft-Versus-Host Disease

Eligibility

Sex: ALLMin age: 7 YearsMax age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects must be 7-30 years of age * Signed informed consent * One of the following three criteria must be met: * Presence of grade II or greater acute GVHD as defined by Keystone criteria * Presence of clinically extensive chronic GVHD as defined by the revised Seattle criteria * Any subject identified prior to allogeneic transplant, or following allogeneic transplant, who is at risk for acute or chronic GVHD Exclusion Criteria: * Inability to meet the requirements of the study procedures * Any subject who is receiving supplemental oxygen * Withdrawal of consent

Locations (1)

Children's Memorial Hospital

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Feasibility - can the procedure be adequately performed in a child?

Time frame: Spring of 2010

Secondary Outcomes

Measure of resting energy expenditure - kcal/day and oxygen consumption (VO2 mL/min)

Time frame: Spring of 2012

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.