Effect of Tamsulosin vs Prazosin in Treatment of Female Voiding Dysfunction

Tabriz University80 enrolled

Overview

The purpose of this study is to determine whether Tamsolusin or Prazosin are effective in the treatment of female voiding dysfunction(BOO)

Voiding dysfunction is not uncommon in Tabriz.About 20% of patients in female urology clinic of Tabriz university of medical sciences sufered from some degrees of voiding dysfunction (due to bladder imparement or bladder outlet obstruction).There is limited information about medical treatment of those patients. On the other hand alpha adrenergic blockers are the first choice medication in BENIGN PROSTATIC HYPERPLASIA. There is some new facts about destribution of alpha adrenergic blockers in female pelvic floor.The purpose of this study is to comparision whether Tamsolusin 0.4/daily or Prazosin 1 mg/daily are effective in the treatment of female voiding dysfunction(BOO)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Neurogenic Bladder

Interventions

tamsolusinDRUG

0.4 mg /day

prazosinDRUG

1 mg/day

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy females with voiding difficulty with MFR\<12 and post void residual urine\>50cc Exclusion Criteria: * History of pelvic floor surgury during last 3 month * Any contraindication for Tamsolusin or prazosin

Outcomes

Primary Outcomes

patient symptoms improvement(Standard questionare)

Time frame: every month untile 3 months

Secondary Outcomes

Urodynamics parameters improvement

Time frame: three months later

Data from ClinicalTrials.gov

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