Deferasirox in Treating Patients With Iron Overload After Undergoing a Donor Stem Cell Transplant

Inclusion Criteria: * Confirmed diagnosis of iron overload, defined as serum ferritin \> 1,000 ng/mL and liver iron concentration ≥ 5 mg iron/g on tissue proton transverse relaxation rates Magnetic Resonance Imaging (MRI) * Underwent prior allogeneic hematopoietic stem cell transplantation (HSCT) using either myeloablative or reduced-intensity conditioning at least 12 months ago * No evidence of relapse or progression of the primary disease for which allogeneic HSCT was performed * Patients who have become red-cell transfusion independent (i.e., no red cell transfusions within the past 3 months) as well as patients who require red cell transfusions are eligible * Meets one of the following criteria: * Ineligible for phlebotomy (hemoglobin \< 11 g/dL, poor intravenous access, or unable to undergo phlebotomy every 4 weeks) * Have failed treatment with phlebotomy (serum ferritin \> 50% of baseline after 3 months of phlebotomy) * Refused phlebotomy * ECOG performance status of 0-2 * Life expectancy ≥ 6 months * Adequate renal function defined as serum creatinine \< or = 1.6 mg/dL and creatinine clearance of \> or = 60 ml/min calculated using the Crockcroft-Gault formula on 2 occasions within 30 days of enrollment * Sexually active men and women must use an effective method of contraception. Alternatively, women must have undergone clinically documented total hysterectomy and/or oophorectomy, or tubal ligation or be postmenopausal. * Must be able to give written informed consent. * Prior therapy with deferoxamine allowed provided it was completed ≥ 12 months ago Exclusion Criteria: * Contraindication for performing MRI or inability to undergo MRI because of claustrophobia or weight (\>350 pounds). * Inability to take medications orally. * Uncontrolled bacterial, viral, or fungal infection * ANC ≥ 1,000/mm³ * Hemoglobin ≥ 8.0 g/dL * Platelet count ≥ 50,000/mm³ * Aspartate aminotransferance (AST) and alanine aminotransferase (ALT) ≤ 5 times the upper limit of normal * Less than 4 weeks since prior and no concurrent systemic investigational drug * Less than 7 days since prior and no concurrent topical investigational drug. Concurrent non-investigational medications needed to treat concomitant medical conditions are allowed, with the exception of other chelating agents. Concurrent growth factors such as epoetin alfa, darbepoetin alfa, filgrastim (G-CSF), and sargramostim (GM-CSF) allowed. Concurrent irradiated packed red-cell and platelet transfusions allowed as clinically indicated. Concurrent low-doses of vitamin C supplements (≤ 200 mg/day) allowed. * Concurrent iron supplements or multivitamins with iron. * Aluminum-containing antacid therapies may not be taken simultaneously with deferasirox, but may be taken 2 hours before or after administration of deferasirox * On dialysis or status post-renal transplantation * Pregnant or nursing