High Dose Rate Prostate Brachytherapy as Salvage for Locally Recurrent Prostate Cancer Previously Treated With External Beam Radiotherapy

Inclusion Criteria: * KPS \> than or equal to 80 * Able to give informed consent * Able to complete toxicity scales and questionnaires * Histologically MSKCC confirmed diagnosis of recurrent prostate cancer. * Documented history of definitive radiotherapy to the prostate gland * IPSS of \< than or equal to 15 at the time of evaluation * PSA \< than or equal to 15 ng/ml * Organ confined disease Exclusion Criteria: * Unable to tolerate general anesthesia * Abnormal complete blood count. Any of the following: * Platelet count less than 75,000/ml * Hb level less than 10 gm/dl * WBC less than 3.5/ml * Abnormal coagulation profile: * INR \> 2.5 * Abnormal Liver function tests (\>1.5 x normal value) * Abnormal renal function tests (creatinine \> 1.5) * Evidence of metastatic disease (bone scan, radiographs, MRI findings) * Prostate volume \> 50 cc * Unable to meet treatment planning criteria * History of rectal surgery * External beam radiation dose to the prostate \> 86.4 Gy if standard treatment planning dose constraints were met * History of inflammatory bowel disease * Expected survival \< 1 year * Unable to undergo bone scan, CT or MRI evaluation * Unavailable for regular follow up