Effect of Licorice and Hydrochlorothiazide on Plasma Potassium

University of Oulu10 enrolled

Overview

This clinical trial is designed to study the effect of the combination of licorice and hydrochlorothiazide on plasma potassium levels in volunteers. In one arm, 10 healthy volunteers will be given 32 grams of licorice a day together with a 25 mg dose of daily hydrochlorothiazide for 14 days. This combination is compared with 32 grams of licorice a day for 14 days given in the other arm. The study is a randomized, open-label cross-over trial. There is at least a 3-week wash-out between the arms. The hypothesis is that the combination of licorice and hydrochlorothiazide will cause hypokalemia. The main outcome measure is the change in the plasma level of potassium between the arms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hypokalemia

Interventions

Hydrochlorothiazide 25 mg a day for 14 days.

LicoriceDIETARY_SUPPLEMENT

Licorice candy 32 grams a day for 14 days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteer * Age 18-40 years Exclusion Criteria: * Any continuous medication * Any significant disease * Hypotension or hypertension * Allergy to licorice or hydrochlorothiazide * Pregnancy and breast feeding * Fear of needles and previous difficult blood samplings * Substance abuse * Participation in another clinical drug trial within 1 month of enrollment

Locations (1)

Oulu University Hospital

Oulu, Finland

Outcomes

Primary Outcomes

Plasma Potassium

Plasma potassium measured with indirect ion specific electrode method

Time frame: Baseline and 2 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.