Duration of Protective Effect From Inhaled Ipratropium Bromide on Methacholine Airway Hyperresponsiveness

University of Saskatchewan12 enrolled

Overview

Certain lung disease medications can influence diagnostic tests and research investigations. This study will investigate how long ipratropium bromide must be withheld before a methacholine challenge test can be conducted. This information will be useful for validating current guidelines.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

TRIPLE

Enrollment

Conditions

Asthma

Interventions

ipratropium bromideDRUG

2 puffs (40 micrograms) 2 puffs (0micrograms)

placeboDRUG

Matched placebo

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of asthma; stable and controlled * FEV1 greater than or equal to 65% predicted Exclusion Criteria: * Concomitant lung disease other than asthma

Locations (1)

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Outcomes

Primary Outcomes

methacholine PC20

Time frame: 6hours and 12 hours post inhalation

Data from ClinicalTrials.gov

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