A Multicenter, Placebo-controlled, Double-blind Investigative Extension Trial of the Safety and Efficacy of Aripiprazole in the Treatment of Patients With Bipolar Disorder Experiencing a Manic or Mixed Episode

Inclusion Criteria: * Trial subjects will be men and women of age 18 or above and below the age of 65 who will not be turning 65 during the trial. * Subjects have the ability to understand and to provide informed consent to the examination, observation, and evaluation processes specified in this protocol, and have signed the informed consent form based on a full understanding of the trial. * Subjects who meet DSM-IV-TR criteria for manic or mixed episodes and have been diagnosed as having "296.4x Bipolar I Disorder in which the most recent episode was manic" or "296.6x Bipolar I Disorder in which the most recent episode was mixed" * Subjects who were enrolled in and have completed Study 003 and who meet the following criteria for demonstration of drug efficacy * Subjects demonstrating drug efficacy: * Those subjects who completed Study 003 whose score for CGI-BP Change From Preceding Phase (mania) at the time of evaluation on Day 21 of Study 003 (completion) was between 1 (Very much improved) and 3 (Minimally improved) Exclusion Criteria: * Subjects presenting with a clinical picture and/or history that is consistent with a DSM-IV-TR diagnosis of: * Delirium, dementia, amnestic disorder, or other cognitive disorders * Schizophrenia or other psychotic disorder * Personality disorder * Subjects with psychotic symptoms that are clearly due to another general medical condition or direct physiological effects of a substance * Subjects who represent a significant risk of committing suicide * Subjects known to have a complication of allergy to aripiprazole or other quinolinone-skeleton compounds * Subjects with a complication of neuroleptic malignant syndrome * Subjects in a state of physical exhaustion accompanied by such conditions as dehydration or malnutrition * Subjects with a complication of paralytic ileus * Subjects with a complication of organic brain disorder or convulsive disorder, such as epilepsy * Subjects with a complication of diabetes