Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma

University of California, San Francisco44 enrolled

Overview

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Asthma

Interventions

FluticasoneDRUG

Inhaled Fluticasone, either 100 or 1000 mcg per day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of asthma Exclusion Criteria: * Habitual cigarette smoking

Locations (1)

University of California, San Francisco

San Francisco, California, United States

Outcomes

Primary Outcomes

FEV1

Time frame: Measured every 2 weeks

Secondary Outcomes

PC20 methacholine

Time frame: Measured every 2 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.