Immunogenicity of the Inactivated Split-Virion Influenza Vaccine in Renal Transplant Subjects

Inclusion Criteria: * Able to attend all scheduled visits and to comply with all trial procedures. * Subject with renal transplant for at least 6 months. * Subject with stable renal function, i.e. with a variation of creatinin value \< 20% and with a creatinin clearance estimated according to Cockroft and Gault calculation \> 20 mL/min during the 3 months preceding inclusion. * Aged 18 to 59 years on the day of the screening visit. * Informed Consent Form signed. * Subject entitled to national social security. * Subject under immunosuppressive therapy. * For a woman, inability to bear a child or negative urine pregnancy test. * Subject non-responder to previous IM vaccination with the 2006-2007 Northern Hemisphere Vaxigrip® formulation. Exclusion Criteria: * Subject with sign of transplanted kidney reject within 3 months preceding vaccination according to medical practice. * Systemic hypersensitivity to any of the vaccine components or history of a life-threatening reaction to the trial vaccine or a vaccine containing the same substances. * Febrile illness (oral temperature ≥ 37.5°C, or rectal equivalent temperature ≥ 38.0°C) on the day of inclusion. * Breast-feeding. * Participation in another clinical trial in the 4 weeks preceding the trial vaccination. * Planned participation in another clinical trial during the present trial period. * Congenital immunodeficiency, anti-cancer chemotherapy or radiation therapy within the preceding 6 months. * Chronic illness, except renal failure or renal disorders, at a stage that could interfere with trial conduct or completion. * Current abuse of alcohol or drug addiction that may interfere with the subject's ability to comply with trial procedures. * Blood or blood-derived products received in the past 3 months . * Any vaccination in the 4 weeks preceding the trial vaccination. * Vaccination planned in the 4 weeks following the trial vaccination. * Thrombocytopenia or bleeding disorder contraindicating intramuscular (IM) vaccination * Previous vaccination against influenza in the preceding 6 months. * Subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent.