Metabolic Disturbances in Polycystic Ovary Syndrome (PCOS)

Hvidovre University Hospital65 enrolled

Overview

The scope of the study was to investigate different metabolic aspects that may lead to or are a consequence of insulin resistance in premenopausal women with polycystic ovary syndrome (PCOS). We use gold standard methods for evaluation of insulin resistance. We take muscle and fat biopsies for investigation of gene expression of different cytokines associated with insulin resistance. We investigate the incretin hormones GIP and GLP-1. These two hormones play a central role in glycemic control, and diabetic subjects are known to have alterations in their incretin hormones. The incretin hormones have not previously been investigated in women with PCOS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Polycystic Ovary Syndrome

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Premenopausal women that meet the Rotterdam criteria for PCOS (BMI \< 40) * Age and BMI matched control women that do not have any signs or symptoms of PCOS Exclusion Criteria: * BMI \> 40. mani fest diabetes or other known diseases

Locations (1)

Dpt. of Obstetrics and Gynaecology, Copenhagen University Hospital, Hvidovre

Hvidovre, Denmark

Outcomes

Primary Outcomes

insulin resistance

Time frame: 2004-2006

Secondary Outcomes

gene expression of cytokines in fatty tissue

Time frame: 2004-2006