Sodium Bicarbonate Versus Saline for the Prevention of Contrast-induced Nephropathy

Ospedale Misericordia e Dolce500 enrolled

Overview

Contrast-induced nephrophaty (CIN) accounts for more than 10% of hospital-acquired renal failure. Hydration with sodium bicarbonate is more protective than isotonic saline in animals. Limited data are available in humans. We compared the efficacy of sodium bicarbonate versus isotonic saline to prevent CIN in a large population of patients with renal dysfunction undergoing coronary angiography or intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

500

Conditions

Contrast-Induced Nephropathy

Interventions

Sodium BicarbonateDRUG

Patients in the sodium bicarbonate group (154 mEq/L) received 3 ml/kg for 1 hour before contrast medium, followed by an infusion of 1 ml/kg/h for 6 hours after the procedure

Isotonic SalineDRUG

Patients assigned to the isotonic saline group received 1 ml/kg/h 0.9% sodium chloride for 12 hours before and after the procedure

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with creatinine clearance \< 60 mL/min Exclusion Criteria: * contrast medium administration within the previous 10 days * end-stage renal failure requiring dialysis * refusal to give informed consent

Locations (1)

Ospedale Misericordia e Dolce

Prato, Prato, Italy

Data from ClinicalTrials.gov

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