Study to Evaluate the Safety, Tolerability and Short Term Efficacy of Extracorporeal Specific Immunoadsorption LupusorbTM Columns for the Treatment of Systemic Lupus Erythematosus (SLE) Patients

Inclusion Criteria: 1. Participants, either male or female are at least 18 years of age at entry. 2. Have diagnosed documented SLE, determined at least by 4 criteria as defined by the American Rheumatism Association ARA 3. Active SLE disease with a SLEDAI score greater than 3 4. Serum anti-VRT101 at least 0.4 O.D. 5. Be willing and able to comply with the protocol for the duration of the study. 6. Participant understands the nature of the procedure and provides written informed consent prior to any study procedure. 7. If female, must be neither pregnant nor breast-feeding and must lack childbearing potential for the duration of the study. Exclusion Criteria: Subjects will be excluded from the study if ANY of the following conditions are present: 1. Patient has Severe proliferative lupus nephritis: 1. Rapidly progressive glomerulonephritis (doubling of serum creatinine during last 3 months); or 2. Severe impairment of renal function Cr more than 2.5 mg/dL 2. Patient Begin immunosuppressive therapy recently: 1. Beginning treatment with azathioprine, mycophenolic acid, cyclosporine or methotrexate within 4 weeks. 2. Cyclophosphamide-an IV pulse within the last 3 months 3. Pulse therapy with glucocorticoids during the 4 weeks before study entry. 4. Patient is in on another experimental therapy. 3. Patient suffers an active or chronic infection. 4. If female, reports pregnancy, breast-feeding (or inadequate birth control) 5. Confounding medical illness that in the judgment of investigators would pose. Added risk for study participants such as: 1. Unstable coronary artery disease, cardiomyopathy or dysrhythmia requiring therapy 2. Hematologic disease (Hb \< 7 G/dL, platelets \< 50,000/dL or WBC \< 2,000/dL). 3. Bleeding tendency 4. Hypogammaglobulinemia (Serum IgG\< 500mg/dL) 6. Participation in another clinical trial within 2 months prior to start of this study. 7. Subject unwilling or unable to comply with the requirements of the protocol. 8. Any condition that the investigator feels would interfere with trial participation and evaluation of the results. 9. Subject unwilling and unable to provide inform consent. 10. Subjects receiving ACE inhibitors treatment 7 days prior to plasmapheresis procedure.