Effect of GLP-1 on Insulin Biosynthesis and Turnover Rates

Phase 2TerminatedNCT00609154

Albert Einstein College of Medicine20 enrolled

Overview

The gut hormone glucagon like peptide-1 (GLP-1) has been shown to have important effects on maintaining the function and health of the insulin producing beta cells. This hormone is known to increase the production rate of new insulin as well as increase the release of insulin into the blood.

We will measure the rate of new insulin production in subjects with Type 2 diabetes compared to non diabetic subjects. We hypothesize that subjects with Type 2 diabetes make less insulin in response to GLP-1 compared to non diabetic subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes

Interventions

glucagon like peptide-1DRUG

GLP-1 1 pmole/kg/min

glucose controlDIETARY_SUPPLEMENT

glucose without GLP-1

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Type 2 Diabetes * Non diabetic Exclusion Criteria: * Currently taking medication such as thiazolidinediones, metformin, Exenatide, or sitagliptin * Chronic condition such as chronic heart failure CHF), Coronary Artery Disease (CAD), or chronic renal failure (CRF) * Anemia

Locations (1)

Albert Einstein College of Medicinie

The Bronx, New York, United States

Outcomes

Primary Outcomes

Insulin Biosynthesis Rate

Blood insulin biosynthesis rate

Time frame: 24 hours

Data from ClinicalTrials.gov

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