Brain Imaging of Psychotherapy for Depression

University of North Carolina, Chapel Hill27 enrolled

Overview

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Major Depressive Disorder

Interventions

Brief Behavioral Activation Treatment for DepressionBEHAVIORAL

Weekly individual therapy sessions

Eligibility

Sex: ALLMin age: 21 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder * For group 1: Hamilton Depression Rating Scale score of 15 or greater Exclusion Criteria: * A history of serious head injury or neurological disease or psychosis * Current use of psychoactive medications * Factors that could affect MRI safety including current or planned pregnancy * For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

Locations (1)

Duke-UNC Brain Imaging and Analysis Center

Durham, North Carolina, United States

Outcomes

Primary Outcomes

Hamilton Depression Inventory

Time frame: three times over 12 weeks

Functional Magnetic Resonance Imaging

Time frame: twice in 12 weeks

Data from ClinicalTrials.gov

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