Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury

Klinikum St. Georg gGmbH82 enrolled

Overview

This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.

In the early period following severe burn injury volume replacement with high amounts of crystalloids is necessary. In this study we compare the organ function scores of a historical patient group, treated with Ringer's Lactate solution, with an actual patient population, treated with Ringer's Acetate solution.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Severe Burn Injury

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>=18 years and \<80years * Burned surface area \>20% and \<70% * Burn injury \< 24 hours * Agreement to the study procedures Exclusion Criteria: * Burned surface area \> 70% * Expected survival time \< 24 hours * Acute or chronic heart failure NYHA III or IV * Adult respiratory distress syndrome * Renal failure * Hepatic failure

Locations (1)

Klinikum St Georg

Leipzig, Saxony, Germany

Outcomes

Primary Outcomes

Change of SOFA-score from day 3 to day 7 after severe burn injury

Time frame: day3, day7, day28, day60

Secondary Outcomes

Changes in electrolyte-balance

Time frame: day3, day7, day28

Data from ClinicalTrials.gov

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