Sacral neuromodulation (SNM) has become an accepted treatment for patients with refractory lower urinary tract dysfunction such as urgency frequency syndrome, urgency incontinence, non-obstructive chronic urinary retention and chronic pelvic pain syndrome. Modulation of central afferent activity is considered critical to this therapeutic effect but the neural mechanisms are poorly understood. We hypothesize that SNM has a significant effect on brain activity detectable by positron emission tomography (PET).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
30
Baseline neuroimaging using PET and MRI of the brain in patients before sacral neuromodulation
Neuroimaging during sacral neuromodulation using PET
Department of Urology, University of Bern
Bern, Switzerland
Effect of sacral neuromodulation on brain activity
Time frame: 2-8 weeks
Differences in brain activity effects of sacral neuromodulation (SNM) in patients with successful compared to failed SNM testing
Time frame: immediately and 2-8 weeks after study inclusion
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