OBJECTIVE: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. DESIGN: Open, prospective, randomized, parallel group, multicentric, comparative trial. SETTING: Out patient clinics of infertility centers in India. PATIENT(S): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given letrozole and twenty-eight patients (68 cycles) were given CC. Both drugs were given orally on days 3-7 of menstrual cycle. INTERVENTION(S): Letrozole, CC, ovulation induction, vaginal micronized progesterone, IUI.
MAIN OUTCOME MEASURE(S): Occurrence of ovulation, endometrial thickness and pregnancy rates.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
55
Tablet Letrozole 2.5 mg once a day for 5 days for 3 cycles
Clomiphene citrate 100 mg or 150 mg once a day for 5 days in 3 cycles
IVF Centre, Chembur,
Mumbai, Maharashtra, India
Ovulation rate (ovulatory cycles/ all treatment cycles) by Ultrasonography (USG).
Time frame: 3 cycles
Pregnancy Rate (Detection of pregnancy by beta-hCG and Ultrasonography) b. Endometrial thickness by Ultrasonography.
Time frame: 3 cycles
Safety
Time frame: 3 cycles
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