Comparison of Atrophogenic Effect of Hydrocortison 1% Cream and Pimecrolimus 1% Cream Assessed by Optical Coherence Tomography (OCT) and 20-MHz Ultrasound of Uninvolved Skin in Patients With Atopic Dermatitis

Phase 2CompletedNCT00610142

Technische Universität Dresden20 enrolled

Overview

to explore the atrophogenic potentials of hydrocortison 1% cream and pimecrolimus 1% cream on unaffected forehead skin

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Atopic Dermatitis

Interventions

pimecrolimus 1% creamDRUG

twice a day one fingertip at a 2 times 2 cm2 area of uninvolved skin on the lateral forehead for 4 weeks

hydrocortison 1% creamDRUG

twice a day one fingertip at a 2 times 2 cm2 area of uninvolved skin on the lateral forehead for 4 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 18-60 years * diagnosis of atopic dermatitis (Hanifin \& Rajka Criteria) * patients with atopic dermatitis not affecting the forehead Exclusion Criteria: * pregnancy / nursing mothers * women in reproductive age without adequate contraception * severe atopic dermatitis (IGA \>= 4) * UV-Therapy in past 4 weeks * patients receiving any topical treatment on the face in past 6 month

Locations (1)

Department of Dermatology, Medical Faculty, TU Dresden

Dresden, Germany

Outcomes

Primary Outcomes

thickness of epidermis

Time frame: 4 weeks

Secondary Outcomes

thickness of dermis

Time frame: 4 weeks

Data from ClinicalTrials.gov

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