Biopsy of Human Tumors for Cancer Stem Cell Characterization: a Feasibility Study

Stanford University40 enrolled

Overview

To see if a limited sampling of tumor tissue from human subjects is a feasible way to gather adequate tissue for cancer stem cell quantification.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Head and Neck Cancer Head and Neck Cancers

Interventions

tumor biopsyPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria:1. Patients with malignant tumors seen at the Stanford University Cancer Center. Eligible patients will have a diagnosis of squamous cell carcinoma (HNSCC) and will have been seen in the Stanford Head and Neck Oncology Program. A decision to undergo surgery at Stanford will have been made, prior to recruiting patients for the study, and prior to obtaining the samples during surgery. (Histological confirmation of the diagnosis need not be made prior to obtaining consent.) 2. A definitive resection of a malignant tumor is planned. 3. Surgeon judgment that the definitive procedure will not be compromised by including * FNA * Core needle biopsy * Cup forceps or punch biopsy of\<4mm. 4. Informed consent documented prior to procedure

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

Quantification of the cancer stem cell population by flow cytometry

Time frame: 1 month

Data from ClinicalTrials.gov

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