Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Erasme University Hospital49 enrolled

Overview

Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Alcoholic Liver Disease Chronic Hepatitis C Virus

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Alcohol excess intake and suspected liver disease * Alcohol excess intake and clinical liver cirrhosis * chronic hepatitis C virus infection and suspected liver disease * chronic hepatitis C virus infection and clinical liver cirrhosis Exclusion Criteria: * bacterial or fungal infection * immunosuppressive treatment * other causes of liver disease

Locations (1)

Hopital Erasme - Dpt of Gastroenterology

Brussels, Belgium

Data from ClinicalTrials.gov

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